PPIPT02502
Target Protein Information
| Protein_Name | Store-operated calcium entry regulator STIMATE |
|---|---|
| Protein_Sequence | MQGPAGNASRGLPGGPPSTVASGAGRCESGALMHSFGIFLQGLLGVVAFSTLMLKRFREPKHERRPWRIWFLDTSKQAIGMLFIHFANVYLADLTEEDPCSLYLINFLLDATVGMLLIYVGVRAVSVLVEWQQWESLRFGEYGDPLQCGAWVGQCALYIVIMIFEKSVVFIVLLILQWKKVALLNPIENPDLKLAIVMLIVPFFVNALMFWVVDNFLMRKGKTKAKLEERGANQDSRNGSKVRYRRAASHEESESEILISADDEMEESDVEEDLRRLTPLKPVKKKKHRFGLPV |
| Organism_Source | Homo sapiens |
| Functional_Classification | SOCE regulator |
| Cellular_Localization | Cytoplasm |
| Gene_Names | STIMATE |
| UniProt_ID | Q86TL2 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | LLLSDPDKVTI |
|---|---|
| Peptide_Sequence | LLLSDPDKVTI |
| Peptide_Length | 11 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(C)C)C(C)C)[C@@H](C)O)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | none |
| Linear/Cyclic | Linear |
| N-terminal_Modification | free |
| C-terminal_Modification | free |
| Amino_Acid_Distribution | |
|
|
|
Peptide Physicochemical
| Molecular_Weight | 1213.44 |
|---|---|
| Aliphatic_Index | 168.18182 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.54545 |
| Charge_at_pH_7 | -1.00142 |
| Isoelectric_point | 4.10925 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 17 |
| Number_of_Hydrogen_Bond_Donors | 16 |
| Topological_Polar_Surface_Area | 486.61000 |
| X_logP_energy | -2.95560 |
Interaction Information
| Affinity | KD=1 uM |
|---|---|
| Affinity_Assay | ELISA |
| PDB_ID | None |
| Type | Agonist |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | Novel peptides, combination of peptides as targets and for use in immunotherapy against gallbladder cancer and cholangiocarcinoma and other cancers |
| Release_Year | 2021 |
| Patent_ID | US20210380662A1 |