PPIPT02505

Target Protein Information
Protein_Name Solute carrier family 35 member E1
Protein_Sequence MAAAAVGAGHGAGGPGAASSSGGAREGARVAALCLLWYALSAGGNVVNKVILSAFPFPVTVSLCHILALCAGLPPLLRAWRVPPAPPVSGPGPSPHPSSGPLLPPRFYPRYVLPLAFGKYFASVSAHVSIWKVPVSYAHTVKATMPIWVVLLSRIIMKEKQSTKVYLSLIPIISGVLLATVTELSFDMWGLVSALAATLCFSLQNIFSKKVLRDSRIHHLRLLNILGCHAVFFMIPTWVLVDLSAFLVSSDLTYVYQWPWTLLLLAVSGFCNFAQNVIAFSILNLVSPLSYSVANATKRIMVITVSLIMLRNPVTSTNVLGMMTAILGVFLYNKTKYDANQQARKHLLPVTTADLSSKERHRSPLEKPHNGLLFPQHGDYQYGRNNILTDHFQYSRQSYPNSYSLNRYDV
Organism_Source Homo sapiens
Functional_Classification Solute carrier (SLC35 family)
Cellular_Localization Plasma membrane
Gene_Names SLC35E1
UniProt_ID Q96K37
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name SAFPFPVTVSL
Peptide_Sequence SAFPFPVTVSL
Peptide_Length 11
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(C)C)C(=O)O
Chemical_Modification None
Cyclization_Method none
Linear/Cyclic Linear
N-terminal_Modification free
C-terminal_Modification free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1164.37
Aliphatic_Index 97.27273
Aromaticity 0.18182
Average_Rotatable_Bonds 2.72727
Charge_at_pH_7 -0.00202
Isoelectric_point 6.10000
Number_of_Hydrogen_Bond_Acceptors 15
Number_of_Hydrogen_Bond_Donors 13
Topological_Polar_Surface_Area 397.43000
X_logP_energy -2.51250
Interaction Information
Affinity KD=10 uM
Affinity_Assay ELISA
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Patent
Title Novel peptides, combination of peptides as targets and for use in immunotherapy against gallbladder cancer and cholangiocarcinoma and other cancers
Release_Year 2021
Patent_ID US20210380662A1