PPIPT02512

Target Protein Information
Protein_Name Proliferation-associated protein 2G4
Protein_Sequence MSGEDEQQEQTIAEDLVVTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDAMIMEETGKIFKKEKEMKKGIAFPTSISVNNCVCHFSPLKSDQDYILKEGDLVKIDLGVHVDGFIANVAHTFVVDVAQGTQVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEAWNKVAHSFNCTPIEGMLSHQLKQHVIDGEKTIIQNPTDQQKKDHEKAEFEVHEVYAVDVLVSSGEGKAKDAGQRTTIYKRDPSKQYGLKMKTSRAFFSEVERRFDAMPFTLRAFEDEKKARMGVVECAKHELLQPFNVLYEKEGEFVAQFKFTVLLMPNGPMRITSGPFEPDLYKSEMEVQDAELKALLQSSASRKTQKKKKKKASKTAENATSGETLEENEAGD
Organism_Source Homo sapiens
Functional_Classification Growth regulatory protein (ErbB3-binding protein)
Cellular_Localization Cytoplasm
Gene_Names PA2G4
UniProt_ID Q9UQ80
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name IAFPTSISV
Peptide_Sequence IAFPTSISV
Peptide_Length 9
Peptide_SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)O)C(C)C)[C@@H](C)CC)[C@@H](C)O
Chemical_Modification None
Cyclization_Method none
Linear/Cyclic Linear
N-terminal_Modification free
C-terminal_Modification free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 934.10
Aliphatic_Index 130.00000
Aromaticity 0.11111
Average_Rotatable_Bonds 2.88889
Charge_at_pH_7 -0.00202
Isoelectric_point 6.10000
Number_of_Hydrogen_Bond_Acceptors 13
Number_of_Hydrogen_Bond_Donors 12
Topological_Polar_Surface_Area 348.02000
X_logP_energy -2.84090
Interaction Information
Affinity KD=20 uM
Affinity_Assay ELISA
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Patent
Title Novel peptides, combination of peptides as targets and for use in immunotherapy against gallbladder cancer and cholangiocarcinoma and other cancers
Release_Year 2021
Patent_ID US20210380662A1