PPIPT02518
Target Protein Information
| Protein_Name | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2 |
|---|---|
| Protein_Sequence | MVVGTGTSLALSSLLSLLLFAGMQMYSRQLASTEWLTIQGGLLGSGLFVFSLTAFNNLENLVFGKGFQAKIFPEILLCLLLALFASGLIHRVCVTTCFIFSMVGLYYINKISSTLYQAAAPVLTPAKVTGKSKKRN |
| Organism_Source | Homo sapiens |
| Functional_Classification | Oligosaccharyltransferase complex subunit |
| Cellular_Localization | Cytoplasm |
| Gene_Names | KRTCAP2 |
| UniProt_ID | Q8N6L1 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | FASGLIHRV |
|---|---|
| Peptide_Sequence | FASGLIHRV |
| Peptide_Length | 9 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)O)C(C)C |
| Chemical_Modification | None |
| Cyclization_Method | none |
| Linear/Cyclic | Linear |
| N-terminal_Modification | free |
| C-terminal_Modification | free |
| Amino_Acid_Distribution | |
|
|
|
Peptide Physicochemical
| Molecular_Weight | 999.18 |
|---|---|
| Aliphatic_Index | 130.00000 |
| Aromaticity | 0.11111 |
| Average_Rotatable_Bonds | 3.44444 |
| Charge_at_pH_7 | 1.08889 |
| Isoelectric_point | 10.55176 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 13 |
| Number_of_Hydrogen_Bond_Donors | 15 |
| Topological_Polar_Surface_Area | 406.93000 |
| X_logP_energy | -2.85973 |
Interaction Information
| Affinity | KD=1 uM |
|---|---|
| Affinity_Assay | ELISA |
| PDB_ID | None |
| Type | Agonist |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | Novel peptides, combination of peptides as targets and for use in immunotherapy against gallbladder cancer and cholangiocarcinoma and other cancers |
| Release_Year | 2021 |
| Patent_ID | US20210380662A1 |