PPIPT02519

Target Protein Information
Protein_Name Lysophosphatidylserine lipase ABHD12
Protein_Sequence MRKRTEPVALEHERCAAAGSSSSGSAAAALDADCRLKQNLRLTGPAAAEPRCAADAGMKRALGRRKGVWLRLRKILFCVLGLYIAIPFLIKLCPGIQAKLIFLNFVRVPYFIDLKKPQDQGLNHTCNYYLQPEEDVTIGVWHTVPAVWWKNAQGKDQMWYEDALASSHPIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERETPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIKFANDENVKHISCPLLILHAEDDPVVPFQLGRKLYSIAAPARSFRDFKVQFVPFHSDLGYRHKYIYKSPELPRILREFLGKSEPEHQH
Organism_Source Homo sapiens
Functional_Classification Serine hydrolase (alpha/beta hydrolase family)
Cellular_Localization Plasma membrane
Gene_Names ABHD12
UniProt_ID Q8N2K0
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name IAIPFLIKL
Peptide_Sequence IAIPFLIKL
Peptide_Length 9
Peptide_SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC)[C@@H](C)CC
Chemical_Modification None
Cyclization_Method none
Linear/Cyclic Linear
N-terminal_Modification free
C-terminal_Modification free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1027.36
Aliphatic_Index 227.77778
Aromaticity 0.11111
Average_Rotatable_Bonds 3.55556
Charge_at_pH_7 0.99769
Isoelectric_point 9.70000
Number_of_Hydrogen_Bond_Acceptors 11
Number_of_Hydrogen_Bond_Donors 10
Topological_Polar_Surface_Area 313.35000
X_logP_energy 2.40500
Interaction Information
Affinity KD=10 uM
Affinity_Assay ELISA
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Patent
Title Novel peptides, combination of peptides as targets and for use in immunotherapy against gallbladder cancer and cholangiocarcinoma and other cancers
Release_Year 2021
Patent_ID US20210380662A1