PPIPT02585

Target Protein Information
Protein_Name POTE ankyrin domain family member D
Protein_Sequence MVAEVCSMPTASTVKKPFDLRSKMGKWCHHRFPCCRGSGKSNMGTSGDHDDSFMKMLRSKMGKCCRHCFPCCRGSGTSNVGTSGDHENSFMKMLRSKMGKWCCHCFPCCRGSGKSNVGAWGDYDHSAFMEPRYHIRREDLDKLHRAAWWGKVPRKDLIVMLRDTDMNKRDKEKRTALHLASANGNSEVVQLLLDRRCQLNVLDNKKRTALIKAIQCQEDECVLMLLEHGADRNIPDEYGNTALHYAIYNEDKLMAKALLLYGADIESKNKCGLTPLLLGVHEQKQQVVKFLIKKKANLNVLDRYGRTALILAVCCGSASIVNLLLEQNVDVSSQDLSGQTAREYAVSSHHHVICELLSDYKEKQMLKISSENSNPEQDLKLTSEEESQRLKVSENSQPEKMSQEPEINKDCDREVEEEIKKHGSNPVGLPENLTNGASAGNGDDGLIPQRRSRKPENQQFPDTENEEYHSDEQNDTRKQLSEEQNTGISQDEILTNKQKQIEVAEQKMNSELSLSHKKEEDLLRENSVLQEEIAMLRLELDETKHQNQLRENKILEEIESVKEKTDKLLRAMQLNEEALTKTNI
Organism_Source Homo sapiens
Functional_Classification Ankyrin repeat-containing protein
Cellular_Localization Cytoplasm
Gene_Names POTED
UniProt_ID Q86YR6
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name POTE553-7A
Peptide_Sequence KILEEIASW
Peptide_Length 9
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCCN)[C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O
Chemical_Modification None
Cyclization_Method none
Linear/Cyclic Linear
N-terminal_Modification free
C-terminal_Modification free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1088.27
Aliphatic_Index 141.11111
Aromaticity 0.11111
Average_Rotatable_Bonds 4.00000
Charge_at_pH_7 -0.99876
Isoelectric_point 4.25815
Number_of_Hydrogen_Bond_Acceptors 14
Number_of_Hydrogen_Bond_Donors 15
Topological_Polar_Surface_Area 432.76000
X_logP_energy -0.99020
Interaction Information
Affinity IC50=0.2 uM
Affinity_Assay T2 binding assay
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Patent
Title Immunogenic pote peptides and methods of use
Release_Year 2015
Patent_ID US20150010590A1