PPIPT02596

Target Protein Information
Protein_Name Eukaryotic translation initiation factor 4E
Protein_Sequence MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
Organism_Source Homo sapiens
Functional_Classification Translation initiation factor
Cellular_Localization Cytoplasm
Gene_Names EIF4E
UniProt_ID P06730
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name STIP-02
Peptide_Sequence KKRYSRELLGX
Peptide_Length 11
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)NCC(=O)NCC(=O)O
Chemical_Modification X8=(R)-2-(4-pentenyl)alanine; X12=(S)-2-(4-pentenyl)alanine
Cyclization_Method Side chain-side chain cyclization; X8<-->X12; other bonds
Linear/Cyclic Cyclic
N-terminal_Modification acetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1306.53
Aliphatic_Index 70.90909
Aromaticity 0.09091
Average_Rotatable_Bonds 4.27273
Charge_at_pH_7 2.99831
Isoelectric_point 10.88576
Number_of_Hydrogen_Bond_Acceptors 19
Number_of_Hydrogen_Bond_Donors 23
Topological_Polar_Surface_Area 607.92000
X_logP_energy -5.80876
Interaction Information
Affinity KD=109.6 nM
Affinity_Assay Surface Plasmon Resonance
PDB_ID 4AZA
Type Inhibitor
Structure
Reference Information
Document_Type Patent
Title STAPLING EIF4E INTERACTING PEPTIDES
Release_Year 2016
Patent_ID US20160046672A1