PPIPT02607

Target Protein Information
Protein_Name Neuronal acetylcholine receptor subunit alpha-7
Protein_Sequence MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
Organism_Source Homo sapiens
Functional_Classification Ligand-gated ion channel (nicotinic acetylcholine receptor)
Cellular_Localization Plasma membrane
Gene_Names CHRNA7
UniProt_ID P36544
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name SERFYECAKEP
Peptide_Sequence SERFYECAKEP
Peptide_Length 11
Peptide_SMILES C[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N1CCC[C@H]1C(=O)O
Chemical_Modification None
Cyclization_Method none
Linear/Cyclic Linear
N-terminal_Modification acetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1358.49
Aliphatic_Index 9.09091
Aromaticity 0.18182
Average_Rotatable_Bonds 3.90909
Charge_at_pH_7 -1.05981
Isoelectric_point 4.47937
Number_of_Hydrogen_Bond_Acceptors 20
Number_of_Hydrogen_Bond_Donors 21
Topological_Polar_Surface_Area 585.81000
X_logP_energy -5.12783
Interaction Information
Affinity IC50=8.4 uM
Affinity_Assay 125I-C-bungarotoxin displacement assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Patent
Title Alpha7 nicotinic receptor peptides as ligands for beta amyloid peptides
Release_Year 2003
Patent_ID US20030092613A1