PPIPT02609

Target Protein Information
Protein_Name Neuronal acetylcholine receptor subunit alpha-7
Protein_Sequence MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
Organism_Source Homo sapiens
Functional_Classification Ligand-gated ion channel (nicotinic acetylcholine receptor)
Cellular_Localization Plasma membrane
Gene_Names CHRNA7
UniProt_ID P36544
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name GIPGKRSERFYECCK
Peptide_Sequence GIPGKRSERFYECCK
Peptide_Length 15
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)CN)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification None
Cyclization_Method none
Linear/Cyclic Linear
N-terminal_Modification acetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1773.06
Aliphatic_Index 26.00000
Aromaticity 0.13333
Average_Rotatable_Bonds 3.93333
Charge_at_pH_7 1.87614
Isoelectric_point 8.79229
Number_of_Hydrogen_Bond_Acceptors 26
Number_of_Hydrogen_Bond_Donors 29
Topological_Polar_Surface_Area 752.83000
X_logP_energy -7.44236
Interaction Information
Affinity IC50=100 uM
Affinity_Assay 125I-C-bungarotoxin displacement assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Patent
Title Alpha7 nicotinic receptor peptides as ligands for beta amyloid peptides
Release_Year 2003
Patent_ID US20030092613A1