PPIPT02611
Target Protein Information
| Protein_Name | Protein E7 |
|---|---|
| Protein_Sequence | MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP |
| Organism_Source | Virus |
| Functional_Classification | Viral oncoprotein |
| Cellular_Localization | Cytoplasm |
| Gene_Names | E7 |
| UniProt_ID | P03129 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | A2.1 |
|---|---|
| Peptide_Sequence | LLMGTLGIV |
| Peptide_Length | 9 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(C)C)[C@@H](C)O)C(=O)N[C@H](C(=O)O)C(C)C |
| Chemical_Modification | None |
| Cyclization_Method | none |
| Linear/Cyclic | Linear |
| N-terminal_Modification | free |
| C-terminal_Modification | free |
| Amino_Acid_Distribution | |
|
|
|
Peptide Physicochemical
| Molecular_Weight | 916.19 |
|---|---|
| Aliphatic_Index | 205.55556 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.33333 |
| Charge_at_pH_7 | -0.00202 |
| Isoelectric_point | 6.10000 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 12 |
| Number_of_Hydrogen_Bond_Donors | 11 |
| Topological_Polar_Surface_Area | 316.35000 |
| X_logP_energy | -0.48620 |
Interaction Information
| Affinity | IC50=8 nM |
|---|---|
| Affinity_Assay | molecular binding assay |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | Immunogenic peptides from the HPV E7 protein |
| Release_Year | 2001 |
| Patent_ID | US20010006639A1 |