PPIPT02622

Target Protein Information
Protein_Name Tumor necrosis factor ligand superfamily member 13B
Protein_Sequence MDDSTEREQSRLTSCLKKREEMKLKECVSILPRKESPSVRSSKDGKLLAATLLLALLSCCLTVVSFYQVAALQGDLASLRAELQGHHAEKLPAGAGAPKAGLEEAPAVTAGLKIFEPPAPGEGNSSQNSRNKRAVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETLPNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL
Organism_Source Homo sapiens
Functional_Classification TNF ligand superfamily
Cellular_Localization Extracellular
Gene_Names TNFSF13B
UniProt_ID Q9Y275
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name AGP3 peptibody
Peptide_Sequence FHDCKWDLLTKQWVCHGL
Peptide_Length 18
Peptide_SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CS)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)O)C(C)C)C(=O)O
Chemical_Modification None
Cyclization_Method none
Linear/Cyclic Linear
N-terminal_Modification free
C-terminal_Modification free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2229.60
Aliphatic_Index 81.11111
Aromaticity 0.16667
Average_Rotatable_Bonds 3.88889
Charge_at_pH_7 0.05616
Isoelectric_point 7.41891
Number_of_Hydrogen_Bond_Acceptors 29
Number_of_Hydrogen_Bond_Donors 31
Topological_Polar_Surface_Area 836.92000
X_logP_energy -3.59880
Interaction Information
Affinity KD=4 pM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Antagonist
Structure
Reference Information
Document_Type Patent
Title Peptides and related molecules that bind to tall-1
Release_Year 2011
Patent_ID EP2292655A1