PPIPT02673

Target Protein Information
Protein_Name Splicing factor U2AF 65 kDa subunit
Protein_Sequence MSDFDEFERQLNENKQERDKENRHRKRSHSRSRSRDRKRRSRSRDRRNRDQRSASRDRRRRSKPLTRGAKEEHGGLIRSPRHEKKKKVRKYWDVPPPGFEHITPMQYKAMQAAGQIPATALLPTMTPDGLAVTPTPVPVVGSQMTRQARRLYVGNIPFGITEEAMMDFFNAQMRLGGLTQAPGNPVLAVQINQDKNFAFLEFRSVDETTQAMAFDGIIFQGQSLKIRRPHDYQPLPGMSENPSVYVPGVVSTVVPDSAHKLFIGGLPNYLNDDQVKELLTSFGPLKAFNLVKDSATGLSKGYAFCEYVDINVTDQAIAGLNGMQLGDKKLLVQRASVGAKNATLVSPPSTINQTPVTLQVPGLMSSQVQMGGHPTEVLCLMNMVLPEELLDDEEYEEIVEDVRDECSKYGLVKSIEIPRPVDGVEVPGCGKIFVEFTSVFDCQKAMQGLTGRKFANRVVVTKYCDPDSYHRRDFW
Organism_Source Homo sapiens
Functional_Classification Spliceosomal regulatory protein
Cellular_Localization Nucleus
Gene_Names U2AF2
UniProt_ID P26368
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name MMDFFNAQM
Peptide_Sequence MMDFFNAQM
Peptide_Length 9
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CCSC)C(=O)O
Chemical_Modification None
Cyclization_Method none
Linear/Cyclic Linear
N-terminal_Modification free
C-terminal_Modification free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1134.35
Aliphatic_Index 11.11111
Aromaticity 0.22222
Average_Rotatable_Bonds 4.11111
Charge_at_pH_7 -1.00157
Isoelectric_point 3.74999
Number_of_Hydrogen_Bond_Acceptors 16
Number_of_Hydrogen_Bond_Donors 13
Topological_Polar_Surface_Area 419.60000
X_logP_energy -2.34310
Interaction Information
Affinity KD=110 uM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Patent
Title ANTIGEN DISCOVERY FOR T CELL RECEPTORS ISOLATED FROM PATIENT TUMORS RECOGNIZING WILD-TYPE ANTIGENS AND POTENT PEPTIDE MIMOTOPES
Release_Year 2020
Patent_ID US20200010527A1