PPIPT02714
Target Protein Information
| Protein_Name | Transcription factor E2F1 |
|---|---|
| Protein_Sequence | MALAGAPAGGPCAPALEALLGAGALRLLDSSQIVIISAAQDASAPPAPTGPAAPAAGPCDPDLLLFATPQAPRPTPSAPRPALGRPPVKRRLDLETDHQYLAESSGPARGRGRHPGKGVKSPGEKSRYETSLNLTTKRFLELLSHSADGVVDLNWAAEVLKVQKRRIYDITNVLEGIQLIAKKSKNHIQWLGSHTTVGVGGRLEGLTQDLRQLQESEQQLDHLMNICTTQLRLLSEDTDSQRLAYVTCQDLRSIADPAEQMVMVIKAPPETQLQAVDSSENFQISLKSKQGPIDVFLCPEETVGGISPGKTPSQEVTSEEENRATDSATIVSPPPSSPPSSLTTDPSQSLLSLEQEPLLSRMGSLRAPVDEDRLSPLVAADSLLEHVREDFSGLLPEEFISLSPPHEALDYHFGLEEGEGIRDLFDCDFGDLTPLDF |
| Organism_Source | Homo sapiens |
| Functional_Classification | E2F transcription factor |
| Cellular_Localization | Nucleus |
| Gene_Names | E2F1 |
| UniProt_ID | Q01094 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | SEQ ID NO:2 |
|---|---|
| Peptide_Sequence | WWRWHF |
| Peptide_Length | 6 |
| Peptide_SMILES | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | none |
| Linear/Cyclic | Linear |
| N-terminal_Modification | free |
| C-terminal_Modification | free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1017.16 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.66667 |
| Average_Rotatable_Bonds | 4.16667 |
| Charge_at_pH_7 | 1.08889 |
| Isoelectric_point | 10.55176 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 9 |
| Number_of_Hydrogen_Bond_Donors | 14 |
| Topological_Polar_Surface_Area | 346.77000 |
| X_logP_energy | 2.46607 |
Interaction Information
| Affinity | IC50=100 uM |
|---|---|
| Affinity_Assay | band shift assay |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | Transcription factor E2F DNA-binding domain inhibitor peptides and their use |
| Release_Year | 2003 |
| Patent_ID | US20030013169A1 |