PPIPT02715

Target Protein Information
Protein_Name Transcription factor E2F1
Protein_Sequence MALAGAPAGGPCAPALEALLGAGALRLLDSSQIVIISAAQDASAPPAPTGPAAPAAGPCDPDLLLFATPQAPRPTPSAPRPALGRPPVKRRLDLETDHQYLAESSGPARGRGRHPGKGVKSPGEKSRYETSLNLTTKRFLELLSHSADGVVDLNWAAEVLKVQKRRIYDITNVLEGIQLIAKKSKNHIQWLGSHTTVGVGGRLEGLTQDLRQLQESEQQLDHLMNICTTQLRLLSEDTDSQRLAYVTCQDLRSIADPAEQMVMVIKAPPETQLQAVDSSENFQISLKSKQGPIDVFLCPEETVGGISPGKTPSQEVTSEEENRATDSATIVSPPPSSPPSSLTTDPSQSLLSLEQEPLLSRMGSLRAPVDEDRLSPLVAADSLLEHVREDFSGLLPEEFISLSPPHEALDYHFGLEEGEGIRDLFDCDFGDLTPLDF
Organism_Source Homo sapiens
Functional_Classification E2F transcription factor
Cellular_Localization Nucleus
Gene_Names E2F1
UniProt_ID Q01094
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name SEQ ID NO:4
Peptide_Sequence IWLSGLSRGWWWSFP
Peptide_Length 15
Peptide_SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)O
Chemical_Modification None
Cyclization_Method none
Linear/Cyclic Linear
N-terminal_Modification free
C-terminal_Modification free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1878.17
Aliphatic_Index 78.00000
Aromaticity 0.33333
Average_Rotatable_Bonds 3.40000
Charge_at_pH_7 0.99798
Isoelectric_point 10.55000
Number_of_Hydrogen_Bond_Acceptors 20
Number_of_Hydrogen_Bond_Donors 25
Topological_Polar_Surface_Area 647.68000
X_logP_energy -0.52833
Interaction Information
Affinity IC50=50 uM
Affinity_Assay band shift assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Patent
Title Transcription factor E2F DNA-binding domain inhibitor peptides and their use
Release_Year 2003
Patent_ID US20030013169A1