PPIPT02717

Target Protein Information
Protein_Name Transcription factor E2F1
Protein_Sequence MALAGAPAGGPCAPALEALLGAGALRLLDSSQIVIISAAQDASAPPAPTGPAAPAAGPCDPDLLLFATPQAPRPTPSAPRPALGRPPVKRRLDLETDHQYLAESSGPARGRGRHPGKGVKSPGEKSRYETSLNLTTKRFLELLSHSADGVVDLNWAAEVLKVQKRRIYDITNVLEGIQLIAKKSKNHIQWLGSHTTVGVGGRLEGLTQDLRQLQESEQQLDHLMNICTTQLRLLSEDTDSQRLAYVTCQDLRSIADPAEQMVMVIKAPPETQLQAVDSSENFQISLKSKQGPIDVFLCPEETVGGISPGKTPSQEVTSEEENRATDSATIVSPPPSSPPSSLTTDPSQSLLSLEQEPLLSRMGSLRAPVDEDRLSPLVAADSLLEHVREDFSGLLPEEFISLSPPHEALDYHFGLEEGEGIRDLFDCDFGDLTPLDF
Organism_Source Homo sapiens
Functional_Classification E2F transcription factor
Cellular_Localization Nucleus
Gene_Names E2F1
UniProt_ID Q01094
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name SEQ ID NO:5
Peptide_Sequence GSRILTFRSGSWYAS
Peptide_Length 15
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method none
Linear/Cyclic Linear
N-terminal_Modification free
C-terminal_Modification free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1687.88
Aliphatic_Index 58.66667
Aromaticity 0.20000
Average_Rotatable_Bonds 3.46667
Charge_at_pH_7 1.99713
Isoelectric_point 11.14762
Number_of_Hydrogen_Bond_Acceptors 24
Number_of_Hydrogen_Bond_Donors 29
Topological_Polar_Surface_Area 731.69000
X_logP_energy -8.64806
Interaction Information
Affinity IC50=100 uM
Affinity_Assay band shift assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Patent
Title Transcription factor E2F DNA-binding domain inhibitor peptides and their use
Release_Year 2003
Patent_ID US20030013169A1