PPIPT02770

Target Protein Information
Protein_Name Somatostatin receptor type 2
Protein_Sequence MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names SSTR2
UniProt_ID P30874
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name DTPA-octreotide
Peptide_Sequence DTPADPFECFDTWKTC
Peptide_Length 16
Peptide_SMILES C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method side chain-side chain; C2<-->C7; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification DTPA
C-terminal_Modification throl
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1876.04
Aliphatic_Index 6.25000
Aromaticity 0.18750
Average_Rotatable_Bonds 3.31250
Charge_at_pH_7 -3.12315
Isoelectric_point 3.69899
Number_of_Hydrogen_Bond_Acceptors 27
Number_of_Hydrogen_Bond_Donors 26
Topological_Polar_Surface_Area 733.94000
X_logP_energy -6.66810
Interaction Information
Affinity IC50=6.3 nM
Affinity_Assay competitive binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Patent
Title METHODS AND COMPOSITIONS FOR IMPROVED F-18 LABELING OF PROTEINS, PEPTIDES AND OTHER MOLECULES
Release_Year 2014
Patent_ID US20140228541A1