PPIPT02797

Target Protein Information
Protein_Name Somatostatin receptor type 2
Protein_Sequence MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names SSTR2
UniProt_ID P30874
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name DTPA-octreotide
Peptide_Sequence fCfwKTCTX
Peptide_Length 9
Peptide_SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)O)C(=O)NCC(=O)O
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C2<-->C7; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification DTPA
C-terminal_Modification threoninol
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1092.30
Aliphatic_Index 0.00000
Aromaticity 0.33333
Average_Rotatable_Bonds 3.44444
Charge_at_pH_7 0.87374
Isoelectric_point 8.22969
Number_of_Hydrogen_Bond_Acceptors 15
Number_of_Hydrogen_Bond_Donors 16
Topological_Polar_Surface_Area 378.39000
X_logP_energy -2.13230
Interaction Information
Affinity IC50=6.3 nM
Affinity_Assay competitive binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Patent
Title METHODS AND COMPOSITIONS FOR IMPROVED F-18 LABELING OF PROTEINS, PEPTIDES AND OTHERMOLECULES
Release_Year 2015
Patent_ID US20150057432A1