PPIST02016

Protein Information
Protein_Chain A[auth L]/B[auth H]
Protein_Sequence ADCGLRPLFEKKSLEDKTERELLESY/IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
Peptide Information
Peptide_Chain C[auth I]
Peptide_Sequence DFEEIPEEYLQ
Peptide_Length 11
Non-standard residues No
Interaction Information
PDB_ID 1T4V
Method X-RAY DIFFRACTION
Resolution 2.00 angstrom
Structure
Protein-peptide residue interaction
Residues
Acidic
Polar
Basic
Aliphatic
Aromatic
Interactions
HBond
WaterBridge
Hydrophobic
SaltBridge
PiStack
PiCation
Halogen
Metal
Interaction_xlsx Download interaction table (.xlsx)
Reference Information
Title Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis
Release_Year 2004
PMID 15203151
DOI 10.1016/j.bmcl.2004.05.002