PPIST06235

Protein Information
Protein_Chain A;B
Protein_Sequence GSHMLETEEEEEEGAGATLSRGPAFPGMGSEELRLASFYDWPLTAEVPPELLAAAGFFHTGHQDKVRCFFCYGGLQSWKRGDDPWTEHAKWFPGCQFLLRSKGQEYINNIHLTHSL
Peptide Information
Peptide_Chain C[auth Y];D[auth Z]
Peptide_Sequence AXPX
Peptide_Length 4
Non-standard residues Yes
Interaction Information
PDB_ID 3UW5
Method X-RAY DIFFRACTION
Resolution 1.71 angstrom
Structure
Protein-peptide residue interaction
Residues
Acidic
Polar
Basic
Aliphatic
Aromatic
Interactions
HBond
WaterBridge
Hydrophobic
SaltBridge
PiStack
PiCation
Halogen
Metal
Interaction_xlsx Download interaction table (.xlsx)
Reference Information
Title Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152).
Release_Year 2012
PMID 22413863
DOI 10.1021/jm300060k