PPIST08460

Protein Information
Protein_Chain A;B;C;D;E;F;G;H;I[auth J]
Protein_Sequence MAPITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMRASKKKKKGSVVIVGRIILSGRK
Peptide Information
Peptide_Chain J[auth K];K[auth L];L[auth M];M[auth N];N[auth O];O[auth P];P[auth Q];Q[auth T];R[auth U]
Peptide_Sequence KGSVVIVGRIILSGRK
Peptide_Length 16
Non-standard residues No
Interaction Information
PDB_ID 4U01
Method X-RAY DIFFRACTION
Resolution 2.80 angstrom
Structure
Protein-peptide residue interaction
Residues
Acidic
Polar
Basic
Aliphatic
Aromatic
Interactions
HBond
WaterBridge
Hydrophobic
SaltBridge
PiStack
PiCation
Halogen
Metal
Interaction_xlsx Download interaction table (.xlsx)
Reference Information
Title Discovery and structural diversity of the hepatitis C virus NS3/4A serine protease inhibitor series leading to clinical candidate IDX320.
Release_Year 2015
PMID 26410074
DOI 10.1016/j.bmcl.2015.09.009