PPIST11962

Protein Information
Protein_Chain A
Protein_Sequence IVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVGYGDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKTQAVHHHHHH
Peptide Information
Peptide_Chain B[auth H]
Peptide_Sequence MDDDDKMDNECTTKIKPR
Peptide_Length 18
Non-standard residues No
Interaction Information
PDB_ID 5QQO
Method X-RAY DIFFRACTION
Resolution 2.00 angstrom
Structure
Protein-peptide residue interaction
Residues
Acidic
Polar
Basic
Aliphatic
Aromatic
Interactions
HBond
WaterBridge
Hydrophobic
SaltBridge
PiStack
PiCation
Halogen
Metal
Interaction_xlsx Download interaction table (.xlsx)
Reference Information
Title Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability.
Release_Year 2019
PMID 31445854
DOI 10.1016/j.bmcl.2019.08.008