PPIST12882

Protein Information
Protein_Chain A;B;C;D
Protein_Sequence GSMSEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVL
Peptide Information
Peptide_Chain E[auth I];F[auth J];G[auth K];H[auth L];I[auth W];J[auth X];K[auth Y];L[auth Z]
Peptide_Sequence XWPPPPTEDELX
Peptide_Length 12
Non-standard residues Yes
Interaction Information
PDB_ID 5NC7
Method X-RAY DIFFRACTION
Resolution 2.70 angstrom
Structure
Protein-peptide residue interaction
Residues
Acidic
Polar
Basic
Aliphatic
Aromatic
Interactions
HBond
WaterBridge
Hydrophobic
SaltBridge
PiStack
PiCation
Halogen
Metal
Interaction_xlsx Download interaction table (.xlsx)
Reference Information
Title Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
Release_Year 2020
PMID 33184177
DOI 10.1073/pnas.2007213117