PPIST12887

Protein Information
Protein_Chain A;B
Protein_Sequence SMAEEVVVVAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERK
Peptide Information
Peptide_Chain C[auth D];D[auth E]
Peptide_Sequence XPPPVPNPDYX
Peptide_Length 11
Non-standard residues Yes
Interaction Information
PDB_ID 5QU2
Method X-RAY DIFFRACTION
Resolution 1.04 angstrom
Structure
Protein-peptide residue interaction
Residues
Acidic
Polar
Basic
Aliphatic
Aromatic
Interactions
HBond
WaterBridge
Hydrophobic
SaltBridge
PiStack
PiCation
Halogen
Metal
Interaction_xlsx Download interaction table (.xlsx)
Reference Information
Title Small molecule AX-024 reduces T cell proliferation independently of CD3娄脜/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain.
Release_Year 2020
PMID 32317279
DOI 10.1074/jbc.RA120.012788