PPIST17509

Protein Information
Protein_Chain A;B;C;G[auth D];H[auth E];I[auth F];M[auth K];N[auth L];O[auth M];S[auth Q];T[auth R];U[auth S]
Protein_Sequence MGSSHHHHHHSSGLVPRGSHMDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNAGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITK
Peptide Information
Peptide_Chain D[auth G];E[auth H];F[auth I];J;K[auth N];L[auth O];P;Q[auth T];R[auth U];V;W[auth X];X[auth Y]
Peptide_Sequence YPVDPICNKPCKTHDDCSGAWFCQTCYYATWSCGWGLRQID
Peptide_Length 41
Non-standard residues No
Interaction Information
PDB_ID 8SE8
Method X-RAY DIFFRACTION
Resolution 3.18 angstrom
Structure
Protein-peptide residue interaction
Residues
Acidic
Polar
Basic
Aliphatic
Aromatic
Interactions
HBond
WaterBridge
Hydrophobic
SaltBridge
PiStack
PiCation
Halogen
Metal
Interaction_xlsx Download interaction table (.xlsx)
Reference Information
Title Cystine-knot peptide inhibitors of HTRA1 bind to a cryptic pocket within the active site region.
Release_Year 2024
PMID 38777835
DOI 10.1038/s41467-024-48655-w